Prof. Dr. Syed Zahid Ali Shah (DVM, MPhil, PhD, Postdoc)
Professor
Post-Doc 2
Other Websites
https://orcid.org/my-orcid?orcid=0000-0002-9638-5800Research Supervision Capacity
About Me
Prof. Dr. Syed Zahid Ali Shah was Born and Raised in District Swabi of Khyber Pakhtunkhwa Province in the North of Pakistan. He is a Professional Veterinarian & Public Health Researcher; he acquired his basic DVM (Doctor of Veterinary Medicine) Degree from University of Veterinary & Animal Sciences Lahore-Pakistan in year 2000. During his bachelor’s degree he developed interest about Therapeutic aspects of Diseases So he enrolled for MSc (Hons) degree at the University of Veterinary & Animal Sciences Lahore and got the degree in the Discipline of Clinical Medicine & Surgery in year 2003. He worked at Veterinary Research Institute Peshawar from year 2004 to 2010 as Research Officer. Later on, he joined University of Agriculture Peshawar as Lecturer in Veterinary Clinical medicine & Surgery in the year 2010. He was Selected for through a prestigious Chinese Government Scholarship to pursue his PhD studies at China Agricultural University Beijing in 2013. During his Stay at China Agricultural University, he was part of a National Transmissible Spongiform Encephalopathy Group, where active Research Activities were conducted on Public Health Related Protein Misfolding Neurodegenerative Diseases including Prion, Alzheimer’s, and Parkinson's Diseases. He Received his PhD Degree in Veterinary Pathology & Public Health in July 2018. After completing the PhD he joined Cholistan University of Veterinary and Animal Sciences as Assistant Professor (Pathology) in 2018 and soon he was offered the position of Head of the Department of Pathology in the following year. He recently joined The Islamia University of Bahawalpur in year 2022 as Professor in the discipline of Pathology at FV&AS. He was Awarded National Institute of Health Fellowship Award for Postdoctoral studies in the year 2022 by Case Western Reserve University Ohio, USA. Upon his return he joined the Department of Pathology as Chairman in 2023. He published several research articles in prestigious international journals with high impact factor. He is working as volunteer reviewer in different Prestigious Journals. His areas of interest are related to Neurobiology and Neurotherapeutics of Protein Misfolding Disorders with Special Emphasis on Prion Diseases, Alzheimer’s Disease & Parkinson’s Disease. His future goals are to Delineate the Signaling Pathways to Understand Molecular Mechanisms of Cellular Responses to Toxic Misfolded protein-induced ER stress. Furthermore, he is interested in doing a Mass Scale Survey on Alzheimer’s & Parkinson’s Disease Prevalence in Pakistan to know the Actual Burden of these Diseases and the Interaction of these Diseases with Other Major Metabolic Diseases such as Diabetes.
Research Interest Keywords
Contact Info
Research Publication
1. Zulqarnain, Ali and Ukasha, Muhammad and Shah, Syed Zahid Ali. 2025. “The Intricate Role of Caspase-6 and Death Receptor-6 in Neurodegenerative Diseases.” Springer Science and Business Media LLC 84. 10.1007/s12013-025-01959-0
2. Wang, Zerui and Wu, Ling and Gerasimenko, Maria and Gilliland, Tricia and Shah, Zahid Syed Ali and Lomax, Evalynn and Yang, Yirong and Gunzler, Steven A. and Donadio, Vincenzo and Liguori, Rocco and Xu, Bin and Zou, Wen-Quan. 2024. “Seeding activity of skin misfolded tau as a biomarker for tauopathies.” Springer Science and Business Media LLC 19. https://doi.org/10.1186/s13024-024-00781-1
3. Zhang, Weiguanliu and Orrú, Christina D. and Foutz, Aaron and Ding, Mingxuan and Yuan, Jue and Shah, Syed Zahid Ali and Zhang, Jing and Kotobelli, Keisi and Gerasimenko, Maria and Gilliland, Tricia and Chen, Wei and Tang, Michelle and Cohen, Mark and Safa. 2024. “Large-scale validation of skin prion seeding activity as a biomarker for diagnosis of prion diseases.” Springer Science and Business Media LLC 147. https://doi.org/10.1007/s00401-023-02661-2
4. Niaz, Kamal and Shah, Syed Zahid Ali and Khan, Fazlullah and Bule, Mohammed. 2020. “Ochratoxin A–induced genotoxic and epigenetic mechanisms lead to Alzheimer disease: its modulation with strategies.” Springer Science and Business Media LLC 27. https://doi.org/10.1007/s11356-020-08991-y
5. Zhang, Xixi and Zhao, Deming and Wu, Wei and Ali Shah, Syed Zahid and Lai, Mengyu and Yang, Dongming and Li, Jie and Guan, Zhiling and Li, Wen and Gao, Hongli and Zhao, Huafen and Zhou, Xiangmei and Yang, Lifeng. 2020. “Melatonin regulates mitochondrial dynamics and alleviates neuron damage in prion diseases.” Impact Journals 12. https://doi.org/10.18632/aging.103328
6. Yang, Dongming and Zhao, Deming and Ali Shah, Syed Zahid and Wu, Wei and Lai, Mengyu and Zhang, Xixi and Li, Jie and Guan, Zhiling and Zhao, Huafen and Li, Wen and Gao, Hongli and Zhou, Xiangmei and Yang, Lifeng. 2020. “Corrigendum: The Role of the Gut Microbiota in the Pathogenesis of Parkinson’s Disease.” Frontiers Media SA 10. 10.3389/fneur.2019.01412
7. Yang, Dongming and Zhao, Deming and Shah, Syed Zahid Ali and Wu, Wei and Lai, Mengyu and Zhang, Xixi and Li, Jie and Guan, Zhiling and Zhao, Huafen and Li, Wen and Gao, Hongli and Zhou, Xiangmei and Yang, Lifeng. 2020. “Implications of gut microbiota dysbiosis and metabolic changes in prion disease.” Elsevier BV 135. 10.1016/j.nbd.2019.104704
8. Hussain, Tariq and Zhao, Deming and Shah, Syed Zahid Ali and Sabir, Naveed and Wang, Jie and Liao, Yi and Song, Yinjuan and Hussain Mangi, Mazhar and Yao, Jiao and Dong, Haodi and Yang, Lifeng and Zhou, Xiangmei. 2019. “PP2Ac Modulates AMPK-Mediated Induction of Autophagy in Mycobacterium bovis-Infected Macrophages.” MDPI AG 20. 10.3390/ijms20236030
9. Zaplatic, Elizabeta and Bule, Muhammed and Shah, Syed Zahid Ali and Uddin, Md. Sahab and Niaz, Kamal. 2019. “Molecular mechanisms underlying protective role of quercetin in attenuating Alzheimer’s disease.” Elsevier BV 224. https://doi.org/10.1016/j.lfs.2019.03.055
10. Hussain, Tariq and Zhao, Deming and Shah, Syed Zahid Ali and Sabir, Naveed and Wang, Jie and Liao, Yi and Song, Yinjuan and Dong, Haodi and Hussain Mangi, Mazhar and Ni, Jiamin and Yang, Lifeng and Zhou, Xiangmei. 2019. “Nilotinib: A Tyrosine Kinase Inhibitor Mediates Resistance to Intracellular Mycobacterium Via Regulating Autophagy.” MDPI AG 8. 10.3390/cells8050506
11. ULLAH, Obaid and LI, Zhongshu and ALI, Ihsan and XU, Lijie and LIU, Haixing and SHAH, Syed Zahid Ali and FANG, Nanzhu. 2019. “Pterostilbene alleviates hydrogen peroxide-induced oxidative stress via nuclear factor erythroid 2 like 2 pathway in mouse preimplantation embryos.” Japanese Society of Animal Reproduction 65. https://doi.org/10.1262/jrd.2018-089
12. Wu, Wei and Zhao, Deming and Shah, Syed Zahid Ali and Zhang, Xixi and Lai, Mengyu and Yang, Dongming and Wu, Xiaoqian and Guan, Zhiling and Li, Jie and Zhao, Huafen and Li, Wen and Gao, Hongli and Zhou, Xiangmei and Qiao, Jian and Yang, Lifeng. 2019. “OPA1 overexpression ameliorates mitochondrial cristae remodeling.” Springer Science and Business Media LLC 10. https://doi.org/10.1038/s41419-019-1953-y
13. Shah, Syed Zahid Ali and Zhao, Deming and Taglialatela, Giulio and Hussain, Tariq and Dong, Haodi and Sabir, Naveed and Mangi, Mazhar Hussain and Wu, Wei and Lai, Mengyu and Zhang, Xixi and Duan, Yuhan and Wang, Lu and Zhou, Xiangmei and Yang, Lifeng. 2019. “Combinatory FK506 and Minocycline Treatment Alleviates Prion-Induced Neurodegenerative Events via Caspase-Mediated MAPK-NRF2 Pathway.” MDPI AG 20. 10.3390/ijms20051144
14. Shah, Syed Zahid Ali and Zhao, Deming and Hussain, Tariq and Sabir, Naveed and Mangi, Mazhar Hussain and Yang, Lifeng. 2018. “p62-Keap1-NRF2-ARE Pathway: A Contentious Player for Selective Targeting of Autophagy.” Frontiers Media SA 11. 10.3389/fnmol.2018.00310
15. Shah, Syed Zahid Ali and Zhao, Deming and Hussain, Tariq and Sabir, Naveed and Mangi, Mazhar Hussain and Yang, Lifeng. 2018. “p62-Keap1-NRF2-ARE Pathway: A Contentious Player for Selective Targeting of Autophagy.” Frontiers Media SA 11. 10.3389/fnmol.2018.00310
16. Shah, Syed Zahid Ali and Zhao, Deming and Hussain, Tariq and Sabir, Naveed and Yang, Lifeng. 2018. “Regulation of MicroRNAs-Mediated Autophagic Flux: A New Regulatory Avenue for Neurodegenerative Diseases With Focus on Prion Diseases.” Frontiers Media SA 10. 10.3389/fnagi.2018.00139
17. ALI, Ihsan and LIU, Hai Xing and ZHONG-SHU, Li and DONG-XUE, Ma and XU, Lijie and SHAH, Syed Zahid Ali and ULLAH, Obaid and NAN-ZHU, Fang. 2018. “Reduced glutathione alleviates tunicamycin-induced endoplasmic reticulum stress in mouse preimplantation embryos.” Japanese Society of Animal Reproduction 64. 10.1262/jrd.2017-055
18. Sabir, Naveed and Hussain, Tariq and Shah, Syed Zahid Ali and Peramo, Antonio and Zhao, Deming and Zhou, Xiangmei. 2018. “miRNAs in Tuberculosis: New Avenues for Diagnosis and Host-Directed Therapy.” Frontiers Media SA 9. 10.3389/fmicb.2018.00602
19. Hussain, Tariq and Zhao, Deming and Shah, Syed Zahid Ali and Wang, Jie and Yue, Ruichao and Liao, Yi and Sabir, Naveed and Yang, Lifeng and Zhou, Xiangmei. 2018. “MicroRNA 27a-3p Regulates Antimicrobial Responses of Murine Macrophages Infected by Mycobacterium avium subspecies paratuberculosis by Targeting Interleukin-10 and TGF-?-Activated Protein Kinase 1 Binding Protein 2.” Frontiers Media SA 8. https://doi.org/10.3389/fimmu.2017.01915
20. Lai, Mengyu and Yao, Hao and Shah, Syed Zahid Ali and Wu, Wei and Wang, Di and Zhao, Ying and Wang, Lu and Zhou, Xiangmei and Zhao, Deming and Yang, Lifeng. 2018. “The NLRP3-Caspase 1 Inflammasome Negatively Regulates Autophagy via TLR4-TRIF in Prion Peptide-Infected Microglia.” Frontiers Media SA 10. 10.3389/fnagi.2018.00116
21. Syed Zahid Ali Shah. 2017. “Role of the AMPK Pathway in Promoting Autophagic Flux via Modulating Mitochondrial Dynamics in Neurodegenerative Diseases: Insight into Prion Diseases.” Ageing Research Reviews 40. https://doi.org/10.1016/j.arr.2017.09.004
22. Li, Chaosi and Wang, Di and Wu, Wei and Yang, Wei and Ali Shah, Syed Zahid and Zhao, Ying and Duan, Yuhan and Wang, Lu and Zhou, Xiangmei and Zhao, Deming and Yang, Lifeng. 2017. “<scp>DLP</scp>1?dependent mitochondrial fragmentation and redistribution mediate prion?associated mitochondrial dysfunction and neuronal death.” Wiley 17. 10.1111/acel.12693
23. Syed Zahid Ali Shah. 2017. “Role of Unfolded Protein Response and Mitogen Activated Protein Kinase Signaling in Neurodegenerative Diseases with Special Focus on Prion Diseases.” Frontiers in Aging Neuroscience 9. https://doi.org/10.3389/fnagi.2017.00120
24. Song, Zhiqi and Shah, Syed Z. A. and Yang, Wei and Dong, Haodi and Yang, Lifeng and Zhou, Xiangmei and Zhao, Deming. 2017. “Downregulation of the Repressor Element 1-Silencing Transcription Factor (REST) Is Associated with Akt-mTOR and Wnt-?-Catenin Signaling in Prion Diseases Models.” Frontiers Media SA 10. 10.3389/fnmol.2017.00128
25. Yang, Wei and Yang, Li?Feng and Song, Zhi?Qi and Shah, Syed Zahid Ali and Cui, Yong?Yong and Li, Chao?Si and Zhao, Hua?Fen and Gao, Hong?Li and Zhou, Xiang?Mei and Zhao, De?Ming. 2017. “PRAS40 alleviates neurotoxic prion peptide?induced apoptosis via mTOR?AKT signaling.” Wiley 23. 10.1111/cns.12685
26. Sabir, Naveed and Hussain, Tariq and Shah, Syed and Zhao, Deming and Zhou, Xiangmei. 2017. “IFN-?: A Contentious Player in Host–Pathogen Interaction in Tuberculosis.” MDPI AG 18. 10.3390/ijms18122725
27. Ali, Ihsan and Shah, Syed Zahid Ali and Jin, Yi and Li, Zhong-Shu and Ullah, Obaid and Fang, Nan-Zhu. 2017. “Reactive oxygen species-mediated unfolded protein response pathways in preimplantation embryos.” XMLink 18. https://doi.org/10.4142/jvs.2017.18.1.1
28. Syed Zahid Ali Shah. 2016. “Central Role for Calcineurin in Protein Misfolding Neurodegenerative Diseases.” Cellular and Molecular Life Sciences 74. 10.1007/s00018-016-2379-7
29. Li, Chaosi and Shah, Syed Zahid Ali and Zhao, Deming and Yang, Lifeng. 2016. “Role of the Retromer Complex in Neurodegenerative Diseases.” Frontiers Media SA 8. 10.3389/fnagi.2016.00042
30. Li, Chaosi and Shah, Syed Zahid Ali and Zhao, Deming and Yang, Lifeng. 2016. “Role of the Retromer Complex in Neurodegenerative Diseases.” Frontiers Media SA 8. 10.3389/fnagi.2016.00042
31. Hassan, Mohammad Farooque and Khan, Sher Hayat and Babar, Masroor Ellahi and Yang, Lifeng and Ali, Tariq and Khan, Jamal Muhammad and Shah, Syed Zahid Ali and Zhou, Xiangmei and Hussain, Tanveer and Zhu, Ting and Hussain, Tariq and Zhao, Deming. 2016. “Polymorphism analysis of prion protein gene in 11 Pakistani goat breeds.” Informa UK Limited 10. https://doi.org/10.1080/19336896.2016.1178422
32. Khan, Sher Hayat and Zhao, Deming and Shah, Syed Zahid Ali and Hassan, Mohammad Farooque and Zhu, Ting and Song, Zhiqi and Zhou, Xiangmei and Yang, Lifeng. 2016. “Parkin Overexpression Ameliorates PrP106–126-Induced Neurotoxicity via Enhanced Autophagy in N2a Cells.” Springer Science and Business Media LLC 37. 10.1007/s10571-016-0407-7
33. Hussain, Tariq and Shah, Syed Zahid Ali and Zhao, Deming and Sreevatsan, Srinand and Zhou, Xiangmei. 2016. “The role of IL-10 in Mycobacterium avium subsp. paratuberculosis infection.” Springer Science and Business Media LLC 14. 10.1186/s12964-016-0152-z
34. Zhao, Sufen and Jia, Yuanyuan and Han, Deping and Ma, Haiyan and Shah, Syed Zahid Ali and Ma, Yunfei and Teng, Kedao. 2016. “Influence of the structural development of bursa on the susceptibility of chickens to infectious bursal disease virus.” Elsevier BV 95. 10.3382/ps/pew192
35. Zhou, Yang and Zhao, Deming and Yue, Ruichao and Khan, Sher Hayat and Shah, Syed Zahid Ali and Yin, Xiaomin and Yang, Lifeng and Zhang, Zhongqiu and Zhou, Xiangmei. 2015. “Inflammasomes-dependent regulation of IL-1? secretion induced by the virulent Mycobacterium bovis Beijing strain in THP-1 macrophages.” Springer Science and Business Media LLC 108. 10.1007/s10482-015-0475-6
36. Z, Ali and S, Khan and I, Ali and H, Rafiullah. 2015. “Comparative Anthelmintic Efficacy of Caesalpinia Crista.” ScopeMed 5. 10.5455/jasa.20150425041541
37. Shah, Syed Zahid Ali and Zhao, Deming and Khan, Sher Hayat and Yang, Lifeng. 2015. “Unfolded Protein Response Pathways in Neurodegenerative Diseases.” Springer Science and Business Media LLC 57. 10.1007/s12031-015-0633-3
38. Wang, Yunsheng and Zhao, Deming and Pan, Bo and Song, Zhiqi and Shah, Syed Zahid Ali and Yin, Xiaomin and Zhou, Xiangmei and Yang, Lifeng. 2015. “Death Receptor 6 and Caspase-6 Regulate Prion Peptide-Induced Axonal Degeneration in Rat Spinal Neurons.” Springer Science and Business Media LLC 56. 10.1007/s12031-015-0562-1
39. Wang, Yunsheng and Zhao, Deming and Pan, Bo and Song, Zhiqi and Shah, Syed Zahid Ali and Yin, Xiaomin and Zhou, Xiangmei and Yang, Lifeng. 2015. “Death Receptor 6 and Caspase-6 Regulate Prion Peptide-Induced Axonal Degeneration in Rat Spinal Neurons.” Springer Science and Business Media LLC 56. 10.1007/s12031-015-0562-1
40. Shah, Syed Zahid Ali and Zhao, Deming and Khan, Sher Hayat and Yang, Lifeng. 2015. “Regulatory Mechanisms of Endoplasmic Reticulum Resident IP3 Receptors.” Springer Science and Business Media LLC 56. 10.1007/s12031-015-0551-4
Research and Development Projects
1. The Role of Tau Isoforms 3R and 4R in Alzheimer's Disease
With: Case Western Reserve University (2022-02 - 2023-02)
In Alzheimer's disease, 3R tau and 4R tau refer to two isoforms of the tau protein, distinguished by the number of microtubule-binding repeat domains they contain. These isoforms are generated by alternative splicing of exon 10 of the MAPT (microtubule-associated protein tau) gene.
2. Large-scale validation of skin prion seeding activity as a biomarker for diagnosis of prion diseases
With: Case Western Reserve University (2022-02 - 2023-12)
Skin prion seeding refers to the presence and amplification of disease-associated prion protein (PrPSc) in the skin of individuals or animals with prion diseases. Although the central nervous system remains the primary site of pathology, increasing evidence shows that the skin can harbor prion seeds capable of inducing misfolding of the normal cellular prion protein (PrPC).
3. Efficacy of Calcineurin Inhibition in Prion Diseases
With: China Agricultural University (2014-09 - 2018-06)
Calcineurin Inhibition is one the major important strategy to prolong life of affected individuals. We worked on a hamster model of Prion Diseases and Used FK506 and Minocycline as modulators of Neurodegenerative events in Prion Diseased animals
The Islamia University of Bahawalpur was established in the year 1975 by upgrading historical institute of the Jamia Abbasia.
