Muhammad Sarfraz
Lecturer
PhD Chemistry
Research Supervision Capacity
About Me
Dr. Muhammad Sarfraz has multidisciplinary research interests spanning organic chemistry, medicinal chemistry, green chemistry, computational chemistry, and computational biology, with emphasis on integrating experimental and computational strategies for drug discovery and sustainable chemical development. His research activities include organic synthesis and medicinal chemistry, focusing on biologically relevant small molecules for lead identification, lead optimization, and precision drug discovery.
Dr. Sarfraz is also interested in structural protein studies and computational biology, particularly the exploration of therapeutically relevant biomolecular targets to support rational drug design and mechanistic understanding of biological systems. In green chemistry, research focuses on deep eutectic solvents (DESs) and natural deep eutectic solvents (NADESs), including the design and synthesis of novel DES systems, their physicochemical properties, and their biological, pharmaceutical, and sustainable chemical applications.
Contact Info
Research Publication
1. Ayyaz, Muhammad and Ali, Danish and Fatima, Arooj and Adnan, Muhammad and Sarfraz, Muhammad. 2026. “A first-principles study evaluating the anticancer and anti-HIV potency of selected plant alkaloids for future drug design.” Elsevier BV 605. https://doi.org/10.1016/j.chemphys.2026.113113
2. Almutairi, Saeedah Musaed and Mehmood, Rabbia and Fatima, Arooj and Ali, Danish and Jamal, Maryum and Ayyaz, Muhammad and Sarfraz, Muhammad. 2025. “Chalcones from the deep: in silico medicinal chemistry and quantum chemical insights into their anticancer and anti-HIV potency.” Elsevier BV 1252. https://doi.org/10.1016/j.comptc.2025.115380
3. Munir, Naima and Gürbüz, Navin and Chaudhry, Gul-e-Saba and Özdemir, ?smail and Sarfraz, Muhammad and ?en, Betül and Aygün, Muhittin and Zafar, Muhammad Naveed. 2025. “Synergistic Antiproliferative Activity of Newly Synthesized Benzimidazole-Based Silver(I) Complexes on MCF-7 and T47D Cell Lines, CT-DNA Interactions Supported by Computational Studies.” American Chemical Society (ACS) 10. https://doi.org/10.1021/acsomega.4c11048
4. Sarfraz, Muhammad and Almutairi, Saeedah Musaed and Wajid, Usba and Imran, Kashaf and Sadia, Mamouna and Ali, Danish and Ayyaz, Muhammad and Yaqoob, Asma and Khan, Zaiba and Elshikh, Mohamed Soliman. 2025. “Biocompatible Deep Eutectic Solvents from Diethylammonium Chloride and Urea: Evaluation of Antioxidant Efficiency and Phytotoxicity.” Wiley 10. https://doi.org/10.1002/slct.202503164
5. Khair-ul-Bariyah, Syeda and Sarfraz, Muhammad and Sharif, Ahsan and Farooqi, Zahoor Hussain and Arshad, Muhammad and Ahmed, Ejaz and Ashraf, Muhammad and Abdullah, Shawana and Arshad, Muhammad Nadeem and Waseem, Amir. 2024. “Novel benzothiazole sulfonamides as potent ?-glucosidase and cholinesterase inhibitors: Design, synthesis, structural properties, biological evaluation and docking studies.” Elsevier BV 1299. https://doi.org/10.1016/j.molstruc.2023.137118
6. Ayyaz, Muhammad and Sarfraz, Muhammad and Arshad, Muhammad and Yaqoob, Asma and Siddique, Sabir Ali and Hussain, Safdar and Ali, Muhammad Arif and Qureshi, Ashfaq Mahmood and Rauf, Abdul. 2024. “Design, Synthesis, In-Vitro Biological Screening and In-Silico Studies of 2-Thioxodihydropyrimidinone Based New Aminomethylene Scaffolds.” Elsevier BV 1299. https://doi.org/10.1016/j.molstruc.2023.137153
7. Sarfraz, Muhammad and Ayyaz, Muhammad and Rauf, Abdul and Yaqoob, Asma and Tooba and Arif Ali, Muhammad and Siddique, Sabir Ali and Qureshi, Ashfaq Mahmood and Sarfraz, Muhammad Hassan and Aljowaie, Reem M. and Almutairi, Saeedah Musaed and Arshad, Muhamm. 2024. “New pyrimidinone bearing aminomethylenes and Schiff bases as potent antioxidant, antibacterial, SARS-CoV-2 and COVID-19 main protease MPro inhibitors: Design, synthesis, bioactivities and computational studies.” American Chemical Society (ACS) 9. https://doi.org/10.1021/acsomega.3c09393
8. El Bakri, Youness and Siddique, Sabir Ali and Mohamed, Shaaban K. and Sarfraz, Muhammad and Abuelizz, Hatem A. and Al-Salahi, Rashad and Mague, Joel T. and Ahmed, Eman A. 2024. “Synthesis, investigation of the crystal structure, DFT calculations, and in silico medicinal potential of hydrazono- and aminomethylene substituted pyrazolidine-3,5-diones as potential anticancer scaffolds.” Royal Society of Chemistry (RSC) 48. https://doi.org/10.1039/D4NJ01839G
9. Akbar, Wajiha and Ehsan, Shahana and Siddique, Sabir Ali and Sarfraz, Muhammad and Shaheen, Faiqa and Shafqat, Ayesha and Shahnaz and Siddique, Muhammad Bilal Ahmed and Saeed, Ayesha and Al-Salahi, Rashad and El Bakri, Youness. 2024. “Solid Phase Synthesis, DFT Calculations, Molecular Docking, and Biological Studies of Symmetrical N2,N4,N6?Trisubstituted-1,3,5- triazines.” American Chemical Society (ACS) 9. https://doi.org/10.1021/acsomega.4c01980
10. Khair-ul-Bariyah, Syeda and Sarfraz, Muhammad and Arshad, Muhammad and Waseem, Amir and Khan, Hidayat Ullah and Khan, Shahnaz and Sharif, Ahsan and Farooqi, Zahoor Hussain and Ahmed, Ejaz. 2024. “Synthesis of 2-Aminothiazole Sulfonamides as Potent Antiurease, Anti ?- Glucosidase, Anti ?-Amylase and Antioxidant Agents: Synthesis, structural properties, biological evaluation and docking studies.” Elsevier BV 10. https://doi.org/10.1016/j.heliyon.2024.e34980
11. Ahmed, Kainat and Bashir, Maryam and Bano, Rehana and Sarfraz, Muhammad and Khan, Hidayat Ullah and Khan, Shahnaz and Sharif, Ahsan and Waseem, Amir and Gilani, Mazhar Amjad and Batool, Komal and Idrees, Rabia and Rauf, Abdul and Saleem, Rahman Shah Zaib. 2023. “Potent heteroaromatic hydrazone based 1,2,4-triazine motifs: synthesis, anti-oxidant activity, cholinesterase inhibition, quantum chemical and molecular docking studies.” Elsevier BV 1284. https://doi.org/10.1016/j.molstruc.2023.135383
The Islamia University of Bahawalpur was established in the year 1975 by upgrading historical institute of the Jamia Abbasia.
